In addition, we excluded 101 participants with CHD, stroke or other cerebrocardiovascular diseases. To minimize the possible influence of medication on glucose and lipid levels, 42 participants using antidiabetic agents and 52 participants using lipid-lowering agents were excluded. Of 22,746 participants who underwent health examination at baseline, 2327 were confirmed to have prehypertension or hypertension. Therefore, individuals taking health examinations in 20 were recruited in this current study as a baseline. The arterial stiffness-related variables, such as baPWV and ankle brachial index (ABI), were available from 2013.
Details of the study design have been described previously. BHMC was designed to investigate the risk factors and biomarkers for metabolism-related diseases, and the recruited individuals were asked to take an annual health examination, including physical examination (anthropometry variables, blood pressures), face-to-face questionnaire survey (demographic variables, lifestyles, diseases history, medication history) and biochemical examination. The BHMC study was conducted based on health examination populations from the Beijing Xiaotangshan Examination Center and Beijing Physical Examination Center. The Beijing health management cohort (BHMC) is an open cohort study established in 2008 in Beijing, China, with new individuals recruited annually. Therefore, we aimed to comprehensively investigate the association between the TyG index and TG/HDL-C ratio with arterial stiffness progression in prehypertensive and hypertensive populations based on a prospective cohort study. Moreover, the association between the TG/HDL-C ratio and arterial stiffness remains unreported. However, this study is a cross-sectional study without follow-up. found that the TyG index is positively associated with brachial-ankle pulse wave velocity (baPWV) in hypertensive patients. However, these studies are all based on general populations. Moreover, IR-related indexes are associated with arterial stiffness. Many studies have found that these surrogate indexes are independent risk factors for some cerebrocardiovascular diseases. Compared with the hyperinsulinaemic-euglycaemic clamp, the TyG index has a high sensitivity of 96.5% and a specificity of 85.0% for the diagnosis of IR, which has also been reported to be associated with diabetes in Chinese population.
Recently, some novel and simple indicators have been reported to be reliable surrogate indexes of IR, such as the triglyceride-glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio. However, this assessment process is expensive and complex and is not ideal for routine clinical monitoring. The hyperinsulinaemic-euglycaemic clamp is the gold standard for evaluating the status of IR. ĭisorders of glucose and lipid metabolism are a common pathophysiological feature accompanying patients with hypertension, while insulin resistance (IR) extensively participates in this biological process. Therefore, it is of great importance to focus on the progression of arterial stiffness in the hypertensive population and identify the early related factors of arterial stiffness. Among hypertensive patients, arterial stiffness is a common vascular complication and is also an independent risk factor and predictor of other cardiovascular and cerebrovascular diseases, such as coronary heart disease (CHD) and stroke. Among Chinese adults aged 35–75 years, nearly half are diagnosed with hypertension, the incidence is still steadily increasing, and the onset age is becoming younger. In 2010, 31.1% of adults around the world were reported to have hypertension. Hypertension has caused a heavy economic burden worldwide, becoming a challenging public health issue. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.